Yavin Shaham, Branch Chief, Intramural Research Program, NIDA-NIH
Lecture summary: In previous studies, we and others have used a rat model of drug relapse and craving to demonstrate time-dependent increases in drug seeking after experimenter-imposed (forced) abstinence from several drugs of abuse (heroin, cocaine, methamphetamine, nicotine), a phenomenon we termed incubation of drug craving (Grimm et al. Nature, 2001; Pickens et al. TINS, 2011). In these studies, the rats were removed from their drug self-administration environment during extended periods of forced abstinence. More recently, we have established a novel rat model in which we observe incubation of drug craving after extended periods of voluntary abstinence in the drug environment. Voluntary abstinence is achieved using a mutually exclusive discrete choice procedure in which food-sated male and female rats with prior extended history of intravenous methamphetamine or heroin self-administaration can choose every day (20 trials per day) between the palatable food and the drug. In this lecture, I will present our initial behavioral, pharmacological, and brain circuit characterization of incubation of drug craving after voluntary abstinence. I will conclude the lecture by discussing the clinical implications of our preclinical results.
Biography: Yavin Shaham received his BS and MA from the Hebrew U, Jerusalem, and his PhD from the Uniformed Services University of the Health Sciences, Bethesda, MD. His postdoctoral training was at Concordia U, Montreal, in the laboratory of Dr. Jane Stewart. Prior to joining the NIDA Intramural Research Program as a tenure-track investigator, he was an investigator at the Addiction Research Center in Toronto. He is currently a tenured Branch Chief and a Senior Investigator. His major awards include the NIDA Director’s Award of Merit (2001), the Society of Neuroscience Jacob Waletzky award for innovative research in drug and alcohol addiction (2006), the NARSAD Distinguished Investigator Grant Award (2016), and the European Behavioral Pharmacology Society Distinguished Achievement Award (2017). He has published over 180 empirical papers, reviews, and commentaries, and his papers were cited over 22,000 times (h-factor: 79; Google Scholar). He currently serves as a Senior Editor for The Journal of Neuroscience and as a Handling (Reviewing) Editor of Neuropsychopharmacology. He is also an editorial board member of Biological Psychiatry, Psychopharmacology, and Addiction Biology. His group currently investigates mechanisms of relapse to heroin, oxycodone, cocaine, and methamphetamine, as assessed in rat models developed in his lab. Most recently, his lab has developed an operant aggression reward model to study mechanisms of relapse to aggressive behavior in mice.
Recent papers and reviews relevant to the lecture
Caprioli D, Venniro M, Zeric T, Li, X, Adhikary S, Madangopal R, Marchant NJ, Lucantonio F, Schoenbaum G, Bossert JM, Shaham Y (2015) Effect of the novel positive allosteric modulator of mGluR2 AZD8529 on incubation of methamphetamine craving after prolonged voluntary abstinence in a rat model. Biological Psychiatry 78:463-473
Venniro M, Caprioli D, Shaham Y (2016) Animal models of drug relapse: from drug priming to incubation of drug craving after voluntary abstinence Progress in Brain Research 224:25-52
Heilig M, Epstein DE, Nader M, Shaham Y (2016) It is time to connect: Addiction neuroscience and social context. Nature Review Neuroscience 17:592-599
Caprioli D, Venniro M, Zhang M, Bossert JM, Warren BL, Hope BT, Shaham Y (2017) Role of dorsomedial striatum neuronal ensembles in incubation of methamphetamine craving after voluntary abstinence. The Journal of Neuroscience 37:1014-1027
Venniro M, Zhang M, Shaham Y, Caprioli D (2017) Incubation of methamphetamine but not heroin craving after voluntary abstinence in male and female rats. Neuropsychopharmacology (in press)
Gaetano Di Chiara
1970, Degree in Medicine and Surgery, Summa cum Laude, Faculty of Medicine and Surgery,University of
Cagliari, Italy with a thesis on the role of 5HT in MK behavior ( see Di Chiara G, Camba R and
Spano PF, Evidence for inhibition by brain serotonin of mouse killing behaviour in rats.
Nature. 1971, 233: 272-273.)
1971-1973, Postdoctoral fellow, Laboratory of Chemical Pharmacology (Bldg.10, NIH, Bethesda, Md,
USA) . Chief : Bernard B.(Steve) Brodie
1973-1975, Military service, medical officer , Mountain artillery Group ‘’Belluno’’ (Tarvisio, Ud), Alpine
1975 -1978 Recipient of a bursary (Borsista) followed by a contract (Contrattista) as a researcher at the
Institute of Pharmacology, University of Cagliari (Director: Prof. GL Gessa)
1978-1980 Assistant professor (Assistente di ruolo) Chair of Pharmacology, Faculty of Medicine and
Surgery, University of Cagliari, Italy.
From 1980, Full Professor (Professore Ordinario) of Pharmacology, Faculty of Medicine and Surgery and
Faculty of Pharmacy, University of Cagliari, Italy
2016, Emeritus Professor (appointed by the University of Cagliari, to be confirmed by the Ministry of
Education, University and Research, MIUR)
Institutional academic functions
1984-1997, Director, Istituto di Farmacologia e Tossicologia sperimentali / Dipartimento di Tossicologia,
University of Cagliari
1997-2006 Dean, School of Pharmacy, University of Cagliari
2007-2009 Director, Centre of Excellence MIUR, ‘’Neurobiology of Addictions’’
1983 & 1989-1991 International Basal Ganglia Society (IBAGS), Co-founder and Secretary
1996-1998 European Behavioural Pharmacology Society (EBPS), President
2000-2002 Federation of European Neuroscience Societes (FENS), President
2000-2005 IBRO Western European Regional Cttee (Chairman)
2005-2007 Società Italiana di Neuroscienze (SINS): President
2005, Commendatore dell’Ordine al Merito della Repubblica ( Carlo Azelio Ciampi, President of the
2002 International Behavioral Neuroscience Society: Outstanding Accomplishement Award
2005 European Brain and Behavior Society: Moruzzi Lecture Award
2015 European Behavioral Pharmacology Society: Distinguished Achievement Award,
Highly Cited Researcher (ISI, 2001) in Neurosciences & Behavior and in Pharmacology & Toxicology
Carmen Sandi is a Professor at the Swiss Federal Institute of Technology Lausanne (EPFL), Switzerland, where she is the Director of the Brain Mind Institute and heads the Laboratory of Behavioral Genetics. She performed her PhD at the Cajal Institute, in Madrid, and had postdoctoral appointments at the University of Bordeaux and the Open University, UK. Before joining the EPFL in 2003, she was Professor at UNED in Madrid where she directed the Laboratory Stress and Memory. More recently, she has been a Distinguished Visiting Scientist Fellow of the Hungarian Academy of Sciences at the Institute of Experimental Medicine in Budapest (2015), Valkhof Chair from the Radboud University in the Netherlands (2015) and Visiting Professor at the Rockefeller University, NY (2016).
Research in her lab aims to understand how stress and personality traits affect brain function and behavior. Her lab is developing an integrative research program combining approaches in rodents and humans focusing on the effects of stress on the social brain. A special emphasis in her current work is placed on the role of brain bioenergetics in the regulation of behavior.
Carmen Sandi She has published over 170 research articles and contributed to various books. She has served in several boards and was the founding Editor-in-chief of Frontiers in Behavioral Neuroscience (2007-2014). She is Inaugural Fellow of the Society for Social Neuroscience (SS4N). She was President of the European Brain and Behavior Society (EBBS; 2011-2012) and is currently member of the Executive council of the European Molecular and Cellular Cognition Society (EMCCS) and President-elect of the Federation of European Neurosciences (FENS).
Recent papers and reviews related to the lecture
Hollis F., van der Kooij M. A., Zanoletti O., Lozano L., Cantó C. and Sandi C. (2015) Mitochondrial function in the brain links anxiety with social subordination. Proc Natl Acad Sci U S A 112: 15486-15491.
Sandi C. and Haller J. (2015) Stress and the social brain: behavioral effects and neurobiological mechanisms. Nature Reviews Neuroscience 16:290-304.
van der Kooij M.A. and Sandi C. (2015) The genetics of social hierarchies. Current Opinion Behavioral Sciences 2: 52-57.
Larrieu T., Cherix A., Duque A., Rodrigues J., Lei H., Gruetter R. and Sandi C. (2017) Hierarchical status predicts behavioral vulnerability and nucleus accumbens metabolic profile following chronic social defeat stress. Current Biology, in press.
van der Kooij, M.A., Hollis, F., Lozano, L., Zanoletti, O., Zalachoras, I., Guillot de Suduiraut M.I., Grosse, J., Abad, S., Canto, C. and Sandi, C. (2017) Diazepam actions in the VTA enhance social dominance and mitochondrial function in the nucleus accumbens by activation of accumbal dopamine D1 receptors. Molecular Psychiatry, in press.
Amy Milton is a Lecturer in the Department of Psychology at the University of Cambridge, UK. She completed her PhD in 2008 in the laboratory of Professor Barry Everitt at Cambridge, before becoming a Research Fellow in Experimental Psychology at Downing College, Cambridge, where she is now the Ferreras-Willetts Fellow in Neuroscience.
Her research focuses on understanding the basic mechanisms of memory reconsolidation – the process by which memories can become unstable under certain conditions of retrieval, and require restabilisation to persist in the brain – and aims to exploit these mechanisms to disrupt the maladaptive emotional memories that contribute to mental health disorders, including drug addiction, post-traumatic stress disorder, and obsessive-compulsive disorder. Her lab combines molecular biological approaches, neuropsychopharmacology, and behavioural analysis in rats, with a strong emphasis on the psychological processes underlying specific behaviours.
Bita Moghaddam is the Chair and Ruth Matarazzo Professor of Neuroscience at Oregon Health and Science University (OHSU). She received a PhD in Biochemistry from the University of Kansas followed by postdoctoral training in pharmacology at Yale University. She joined the faculty of the Department of Psychiatry and Neurobiology at Yale University in 1990 where she quickly rose to the rank of full professor. In 2003 she moved to the University of Pittsburgh as professor of Neuroscience and Psychiatry. She joined OHSU in 2017. Her research focuses on understanding the neuronal basis of complex behaviors that are critical to mental health, and is distinguished by the substantial impact on the field (H-index 70, overall citations ~ 15,000). Her work has led to the discovery of one of the first non-monoamine targeting compound (targeting metabotropic glutamate receptors) for treatment of schizophrenia. Her research has been funded continuously since 1991, including a MERIT award from the National Institute of Mental Health. She has been an active educator and mentor throughout her scientific career. She is an elected fellow of ACNP and the recipient of several prestigious research awards, including the Efron award for excellence in research related to neuropsychopharmacology and the Paul Jansen Award for excellence in schizophrenia research. She has served on numerous editorial and advisory boards as well as national and local educational and service-oriented committees.
Wood, J., Simon, N.W., Koerner, S., Kass, R.E., Moghaddam, B. (2017). Networks of VTA Neurons Encode Real-Time Information about Uncertain Numbers of Actions Executed to Earn a Reward. Frontiers in Neuroscience, in press
Del Arco, A., Park, J., Wood, J., Kim, Y., Moghaddam, B. (2017). Adaptive encoding of outcome prediction by prefrontal cortex ensembles supports behavioral flexibility. Journal of Neuroscience, in press
Bueno-Junior, L.S., Simon, N.W., Wegener, M.A., Moghaddam, B. (2017). Repeated Nicotine Strengthens Gamma Oscillations in the Prefrontal Cortex and Improves Visual Attention Neuropsychopharmacology 42 (8), 1590-1598
Park, J. and Moghaddam, B. (2016) Impact of anxiety on prefrontal cortex encoding of cognitive flexibility. Neuroscience, doi: 10.1016/j.neuroscience.2016.06.013.
Lohani, S., Poplawsky, A.J., Kim, S.G., and Moghaddam, B.(2016) Unexpected global impact of VTA dopamine neuron activation as measured by opto-fMRI. Molecular Psychiatry,doi:10.1038/mp.2016.102
Park, J., Wood, J., Bondi, C., Del Arco, A., and Moghaddam, B. (2016) Anxiety evokes hypofrontality and disrupts rule-relevant encoding by dorsomedial prefrontal cortex neurons. Journal of Neuroscience,36(11): 3322-3335.
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